Organic Chemistry 1
Jeff Corkill
Eastern Washington University,
Cheney, WA

LECTURE NOTES

0. Grade Plot
00. More organic lecture notes: this time from the Netherlands
1a.Why should I study organic chemistry? Top 10 reasons why!

1b.Why should I study organic chemistry? An essay!
1c. Advice from OChem instructors of HOW to study organic chemistry
1d Learning Tips for Organic Chemistry: i.e. "learning for understanding"

2. What should I know from general chemistry?
3. The scientific method

4a What's the big deal about CARBON?
4b. IMPORTANT IDEAS IN ORGANIC CHEMISTRY
5. Definitions and basic themes of organic chemistry
6. The history of organic chemistry
7. Biochemistry
8. Organic Chemistry list of abbreviations

The 17 GOLDEN RULES of ORGANIC CHEMISTRY
9. The theory of bonding, quantum mechanics and organic chemistry
10a. Table of Bond dissociation energies
10b. Table of typical bond lengths
11. Formal Charges
12.Units

THE INFLUENCE OF BONDING & STRUCTURE ON PHYSICAL PROPERTIES
13a Introduction to hybridisation (from University of Illinois)
13b. Polar bonds & polarity
14. Non covalent interactions [NCI] waters associating by NCIs
15a. Soaps on the molecular level: a primer lipid bilayer
15b. The chemical structures of triglycerides (aka 'fats and oils')
Click on images to enlarge<=stearic acid<=linolenic acid<=phospholipid (membrane component)
16. Trends in melting & boiling points and solubilibities

THE ELECTRONIC STRUCTURES OF ORGANIC COMPOUNDS
17a.Resonance and delocalisation 
17b.Rules for writing resonance structures
17c. Illustrated view of +/- R and I groups
18. Conjugation
19. Aromaticity

THE STRUCTURE-ACTIVITY RELATIONSHIP IN ORGANIC CHEMISTRY

20. RELATIVE acidities and basicities  
21A. Structural & electronic factors which influence pKa [long!]
21B: pKa, structure and electronic effects: a case study

ALKANES & FUNCTIONAL GROUPS

22a. Writing structures and naming in organic chemistry: isomers #1
22b: Index of hydrogen deficiency calculations
22c. IUPAC Functional Groups Priority List

23a. Structural Analysis of Organic Compounds
23b. Spectral Database for Organic Compounds SDBS  (sneaky way to get from MF to possible structural isomers)
PETROLEUM CHEMISTRY
25a. Crude oil to products- a flow chart
25b. More diagrams of petroleum products   (1) the simple version (2) the full story
25c. Information on  ignition, pre-ignition & "octane number"
25d. Review of petroleum refining processes from Australiaoil refinery <=An oil refinery

25e. Fractionation (distillation) tower: a figure=>......Composition of fractions from initial distillation=>
25f. Redox reactions of energy [ATP] production in vivo: a diagram

ALKANES & CYCLOALKANES: conformational analysis

 26. Conformations of acyclic compounds: ISOMERS #2
27. Cycloalkanes
28a: Saccharides: structure/activity/biological function relations for poly-glucoses
28b. Structures of bacterial cell walls and Gram positive/negative binding sites
24. Stabilities & Reactions of radicals
ALKENES
29. Properties of Alkenes
30. Reactions of Alkenes: NEW!This includes:
a. General Introduction,
b. Table of relative stabilities of carbocations: to get this directly click here! and yet another  'go' at relative stabilities of those carbocations
c. Table of reactions of alkenes: to get this directly click here!
Alkene Lecture Notes from University of Illinois, Chicago   Best viewed usingCHIME plug-in (click here to get this now)click to get CHIME
d. Diagram of ALKENE reactions by type of alkene and inorganic reagent:click here!
31. Sex hormones, Epoxides, Smoke and Pharmacogenetics information
STEREOCHEMISTRY 

34. Stereochemistry NEW!
35a. Stereochemistry concept map
b. Chiral Pharmaceutics: lecture Poerpoint slides from Univ of Maryland
  <=Sales of chiral drugs

c. Chiral drugs: a primer from Adelaide, Oz
d. Stereochemistry Lecture Notes (and self quizzes!) from University of Illinois, ChicagoBest viewed usingclick to get CHIMECHIME plug-in (click here to get this now)

ALKYNES and RETROSYNTHESIS

32. Alkynes (1) Alkyne reactions: table and descriptions  (2) Concept diagram <=click
33a. Retrosynthesis design synthesis for brevetoxin A<=click to see structure!!!!!

33b. Example of a company that specialises in computer driven retrosynthesis software

ALKYL HALIDES (HALOALKANES)
SUBSITUTION & ELIMINATION

36a: Alkyl Halides: Introduction and mainly radical reactions now (since 2010) covered in CHEM 352
CHEM 351: OChem 1
36b: Part A: SN1 reactions
37c: Part B: SN2 reactions
37d: Part C: Elimination reactions E1 and E2
37e.
Fairly complete charts of
SN versus E reactions for the different types of alkyl halides, nucleophiles, bases, leaving groups and solvents
37f: Table of SN versus E reactions (courtesy of Kevin Hansen, M.D., a former 351 student)


"Metabolic" Chart: concept map for retrosynthesis for recations in CHEM351


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